pentobarbital will minimize the level or impact of fosamprenavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will decrease the level or outcome of ibuprofen by impacting hepatic enzyme CYP2C9/10 metabolism. Small/Significance Unidentified.pentobarbital will decrease the extent or effect of buprenorphi